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Phentermine’s History

Phentermine was first approved by the FDA for use as an appetite suppressant in 1959, following a series of successful tests on rats. It entered the market in its current form, as Phentermine hydrochloride, and became available in the 1970s for personal use.

Since the drugs approval in 1959 no clinical studies have been conducted to test the various long term effects of Phentermine. In 1990, Phentermine was combined with Fenfluramine and became known as Fen-Phen. Fen-Phen was never approved by the FDA, though various clinical studies were published. The general consensus was that Fen-Phen was more effective than Phentermine and had fewer side effects. However, Fen-Phen was voluntarily removed from the market at the request of the FDA when it was discovered that nearly 30% of the people taking Fen-Phen had abnormal heart valve findings.

Phentermine is well known throughout the diet supplement industry as it is one of the oldest and most established ingredients in the industry. New appetite suppression methods, such as Hoodia Gordonii, are showing to be just as effective as Phentermine without the negative side effects.